Urs Hafeli

U R S    H A F E L I

 

Assistant Professor

Division of Pharmaceutics and Biopharmaceutics

Faculty of Pharmaceutical Sciences

The University of British Columbia

2146 East Mall

Vancouver, B.C. V6T 1Z3

CANADA

 

Tel:  (604) 822-7133       Fax (604) 822-3035

Web-site: http://www.magneticmicrosphere.com

E-mail: uhafeli@interchange.ubc.ca

 

Training:

 

1980-1985: B. Sc. in Pharmacy, Federal Institute of Technology (ETH), Zurich, Switzerland

1986-1989: Ph.D. in Pharmaceutics, Paul Scherrer Institute, Radioisotope Department, Villigen, Switzerland

                   Thesis entitled "Liposomes as Carriers of the Beta-Emitters Rhenium-186 and Rhenium-188 for

                    Application in Radiotherapy"

1991-1993: Postdoctoral Research Fellow, Harvard Medical School, Joint Center for Radiation Therapy,

                   Boston, MA, U.S.A.

 

Professional Experience:

 

1990:          Project Scientist, Paul Scherrer Institute, Villigen, Switzerland

1993-2004: Staff Scientist, The Cleveland Clinic Foundation, Radiation Oncology Department, Cleveland,

                   OH, U.S.A.

1996 -   :     Organizer of the bi-yearly meeting "Scientific and Clinical Applications of Magnetic Carriers"

2004 -   :     Assistant Professor, Faculty of Pharmaceutical Sciences, University of British Columbia,

                    Vancouver, BC, Canada

 

Research Interests:

 

1.      Preparation of growth factor-releasing magnetic microspheres and their testing in vivo in a diabetic leg

      ulcer model.

2.      Ongoing laboratory research and testing of different radioactive and magnetic microspheres for tumor

      brachytherapy.

3.      Synthesis of poly(L-lactic acid) derivatives to bind the radioisotopes In-111, Y-90 and Re-186/188 more

      quickly and with higher affinity.

4.      Characterization of the magnetic forces necessary for in vivo movement of magnetic microspheres.

5.      Toxicological tests of different particles in vitro and in vivo.

6.      Dosimetric evaluation of brachytherapy systems with gafchromic film.

7.      Preparation and use of radioactive Re-188 stents for lung cancer treatment.

8.      Treatment of brain tumors with a radioactive fibrin glue.

 

Patents

 

1.      Häfeli U. O., Landau U. and Warburton M. C., Method of making a radioactive stent, U.S.

      Patent № 6,413,271 (July 2, 2002)

2.      Ciezki J. P., Häfeli U. O. and Bleam D., Method and apparatus for intravascular brachytherapy treatment

      planning, U.S. Patent № 6,494,835 B1 (December 17, 2002)

3.      Häfeli UO, Landau U, Warburton MC. Method of making a radioactive medical device. U.S.

      Patent № 6,077,413 (June 20, 2000)

4.      Lee EJ, Häfeli U, Jung EJ. Radiation source with delivery wire. U.S.

      Patent № 6,024,690 (February 15, 2000)

Publications

 

1.      Algur E, Macklis RM, Häfeli UO. Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer and myeloma cell lines. Int J Radiat Oncol Biol Phys 61, 535-542 (2005)

2.      Iacob G, Rotariu O, Strachan NJC, Häfeli UO. Magnetizable needles and wires - modeling an efficient way to target magnetic microspheres in vivo. Biorheology 41, 599-612 (2004)

3.      Zhang H. and Häfeli U. O., Preparation and characterization of radioactive Co/188Re stents intended for lung cancer treatment using an electrodeposition method, J. Med. Eng. Technol. 28, 197-204 (2004)

4.      Häfeli U. O., Zhang H., Bahrehmand F. and Reynaert N., Development of an automated electroplater and dosimetry system for the electrodeposition and quality control of radioactive stents, Appl. Radiat. Isot. 61, 1313-1321 (2004)

5.      Häfeli U. O., Magnetically modulated therapeutic systems, Int. J. Pharm. 277, 19-24 (2004)

6.      Cao J., Wang Y., Yu J., Xia J., Wang C., Yin D., Hafeli U. O., Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy, JMMM 277, 165-174 (2004)

7.      Gupta S., Adhami V. M., Subbarayan M., MacLennan G. T., Lewin J. S., Häfeli U. O., Fu P., Mukhtar, H., Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model, Cancer Res., 64 3334-3343 (2004)

8.      Häfeli U. O., Yu J., Farudi F., Li Y. and Tapolsky G., Radiolabeling of magnetic targeted carriers (MTC) with indium-111, Nuclear Medicine & Biology, 30 761-769 (2003)

9.      Yu J., Sands M. J., Dong Y. and Häfeli U. O., 90Y-oxine-ethiodol, a potential radiopharmaceutical for the treatment of liver cancer, Appl. Radiat. Isot., 58 567-573 (2003)

10.  Kaminski M. D., Nunez L., Ghebremeskel A. N. et al., Magnetically responsive microparticles for targeted drug and radionuclide delivery. A review of recent progress and future challenges. Argonne, IL: Argonne National Laboratory ANL-03/28, 1-92 (2003)

11.  Subbarayan M., Häfeli U. O., Feyes D. K., Unnithan J., Emancipator S. N. and Mukhtar H., A simplified method for the preparation of 99mTc-annexin V and its biological evaluation for in vivo imaging of apoptosis after photodynamic therapy, J. Nucl. Med., 44 650-656 (2003)

12.  Reynaert N. and Häfeli U. O., Response to Dr. Janicki's letter to the editor [Med. Phys. 29, 260 (2002)], Med. Phys., 29 261 (2002)

13.  Yu J. F., Häfeli U. O., Dong Y. et al., Radiolabeling of magnetic targeted carriers with several therapeutic and imaging radioisotopes, Eur. Cells Mat., 3 Suppl. 2 16-18 (2002)

14.  Häfeli U. O., Ciocan R. and Dailey J. P., Characterization of magnetic particles and microspheres and their magnetophoretic mobility using a digital microscopy method, Eur. Cells Mat., 3 Suppl. 2 24-27 (2002)

15.  Rudershausen, S., Häfeli, U. O., Grüttner, C. & Teller, J. Novel chelator containing particles specific for controlled radioisotope delivery. Journal of Labelled Compounds and Radiopharmaceuticals 44, S838-S840 (2001)

16.  Häfeli, U. O., Pauer, G. J. & Miller, D. D. Feasibility study for the treatment of metastatic prostate cancer with the radioactive antiandrogen I-125-bicalutamide (I-125 Casodex). Journal of Labelled Compounds and Radiopharmaceuticals 44, S670-S672 (2001)

17.  Häfeli U, Pauer G, Failing S et al. Radiolabeling of magnetic particles with rhenium-188 for cancer therapy. Journal of Magnetism and Magnetic Materials 225, 73-78 (2001)

18.  Häfeli UO, Roberts WK, Pauer GJ et al. Preparation and stability of biodegradable radioactive rhenium microspheres (Re-186 and Re-188) for use in radiotherapy. Applied Radiation and Isotopes 54, 869-879 (2001)

19.  Erzurum VZ, Häfeli UO, Hirko MK et al. Local application of beta-particle radiation to reduce venous anastomotic intimal hyperplasia in polytetrafluorethylene arteriovenous fistulas. Vascular Surgery 34,    377-383 (2000)

20.  Evans EE, Häfeli UO, Wusirika R et al. Diamond like carbon coatings for rhenium stents. Amorphous and nanostructured carbon 593, 433-438 (2000)

21.  Häfeli UO, Roberts WK, Meier DS et al. Dosimetry of a W-188/Re-188 beta line source for endovascular brachytherapy. Medical Physics 27, 668-675 (2000)

22.  Ciezki JP, Häfeli UO, Song P et al. Parenchymal cell proliferation in coronary arteries after PTCA: A human tissue bank study. International Journal of Radiation Oncology Biology Physics 45, 963-968 (1999)

23.  Häfeli UO, Casillas S, Dietz DW et al (1999). Radioembolization of Novikoff hepatomas using radioactive rhenium (Re-186/Re- 188) glass microspheres. International Journal of Radiation Oncology Biology Physics 44, 189-199.

24.  Häfeli UO, Lee EJ, Ciezki J et al (1999). Suitability of beta-emitting rhenium for inhibiting restenosis in coronary arteries. Journal of Brachytherapy International 15, 1-11.

25.  Häfeli UO, Pauer GJ. In vitro and in vivo toxicity of magnetic microspheres. Journal of Magnetism and Magnetic Materials 194, 76-82 (1999) PDF

26.  Roberts WK, Häfeli UO. Modeling rhenium-186 and rhenium-188 distribution in a neutron-activated rhenium wire and effect of the distribution on beta dosimetry in a water phantom. Applied Radiation and Isotopes 51, 543-549 (1999) PDF

27.  Schütt W, Grüttner C, Teller J et al. Biocompatible magnetic polymer carriers for in vivo radionuclide delivery. Artificial Organs 23, 98-103 (1999) link

28.  Conzone SD, Häfeli UO, Day DE et al. Preparation and properties of radioactive rhenium glass microspheres intended for in-vivo radioembolization therapy. Journal of Biomedical Materials Research 42, 617-625 (1998) link

29.  Häfeli UO, Warburton MC, Landau U. Electrodeposition of radioactive rhenium onto stents to prevent restenosis. Biomaterials 19, 925-933 (1998) link

30.  Schütt W, Grüttner C, Häfeli U et al. Applications of magnetic targeting in diagnosis and therapy - possibilities and limitations. A mini-review. Hybridoma 16, 109-117 (1997) PDF

31.  Gallo JM, Häfeli U. Correspondence re: A.S. Lübbe et al., Preclinical and clinical experiences with magnetic drug targeting. Cancer Research 57, 3063-3064 (1997) link

32.  Häfeli UO, Pauer GJ, Macklis RM. Treatment of mouse tumors with radioactive magnetic microspheres: Model for intracavitary radiotherapy. Proceedings of the International Symposium on Controlled Release of Bioactive Materials 22, 89-90 (1995)

33.  Häfeli UO, Sweeney SM, Beresford BA et al. Effective targeting of magnetic radioactive Y-90-microspheres to tumor cells by an externally applied magnetic field. Preliminary in vitro and in vivo results. Nuclear Medicine and Biology - International Journal of Radiation Applications and Instrumentation Part B 22, 147-155 (1995) PDF

34.  Häfeli UO, Sweeney SM, Beresford BS et al. Biodegradable magnetically directed Y-90-microspheres: Novel agents for targeted intracavitary radiotherapy. Journal of Biomedical Materials Research 28, 901-908 (1994) link

35.  Häfeli U, Atcher RW, Morris CE et al. Polymeric radiopharmaceutical delivery systems. Radioactivity & Radiochemistry 3, 11-14 (1992)

36.  Häfeli U, Tiefenauer LX, Schubiger PA et al. A lipophilic complex with Re-186/Re-186 incorporated in liposomes suitable for radiotherapy. Nuclear Medicine and Biology - International Journal of Radiation Applications and Instrumentation Part B 18, 449-454 (1991)

37.  Book. Häfeli U, Schütt W, Teller J et al (1997). Scientific and clinical applications of magnetic carriers, 1st edn. Plenum, New York.

38.  Book Chapters. Arshady R., Pouliquen D., Halbreich A. et al., Magnetic nanospheres and nanocomposites, in: Arshady R., ed, MML Series. Vol. 5. London: Citus Books, pp. 283-328 (2002)

39.  Roffi M., Tuzcu E. M., Whitlow P. L., Häfeli U. O. and Ciezki J. P., Intravascular Ultrasound-guided catheter-based system, in: Waksman R., ed, Vascular Brachytherapy. 3rd ed. Armonk, NY: Futura Publishing Co., pp. 827-837 (2002)

40.  Häfeli U. O. Chapter 18: Radioactive magnetic microspheres. In: Arshady R (ed) Microspheres, Microcapsules & Liposomes: Magneto- and Radiopharmaceuticals, vol 3. Citus Books, London, 559-584 (2001)

41.  Häfeli U. O. Radioactive microspheres for medical applications. In: Bulte J, de Kuyper M (eds) Focus on biotechnology. Kluwer Academic Publishing, 213-248 (2001)

42.  Häfeli U. O. The history of magnetism in medicine. In: Andrä W, Nowak H (eds) Magnetism in medicine: A handbook. Wiley-VCH, Berlin, 15-34 (1997)

43.  Häfeli U. The mystery and history of magnetism. In: Häfeli U, Schütt W, Teller J et al (eds) Scientific and clinical applications of magnetic carriers, 1st edn. Plenum, New York, 1-10 (1997)

44.  Häfeli U. O, Pauer GJ, Roberts WK et al. Magnetically targeted microspheres for intracavitary and intraspinal Y-90 radiotherapy. In: Häfeli U, Schütt W, Teller J et al (eds) Scientific and clinical applications of magnetic carriers, 1st edn. Plenum, New York, 501-516 (1997)

45.  Kraeft S. K, Häfeli U. O, Chen L. B. Analysis of microspheres in living cells by confocal microscopy. In: Häfeli U, Schütt W, Teller J et al (eds) Scientific and clinical applications of magnetic carriers. Plenum, New York, 149-161 (1997)

46.  Häfeli U, Ciezki J, Lee E et al (1997). Development of a metallic radioactive rhenium source for the treatment of restenosis after angioplasty. In: Bryskin BD (ed) Rhenium and Rhenium Alloys. TMS (Minerals, Metals and Materials Society), Warrendale, PA, 461-468.

47.  Häfeli U, German R, Pauer G et al (1997). Production of Rhenium-Powder with a jet mill and its incorporation in radioactive microspheres for the treatment of liver tumors. In: Bryskin BD (ed) Rhenium and Rhenium Alloys. TMS (Minerals, Metals and Materials Society), Warrendale, PA, 469-477.

 

M Y    C O L L E A G U E S

 

 

 

 

JIM  WATSON,  Professor,  Doctor of sciences.

Department of Physics and Astronomy, University of Southampton, England, is an authority in the field of high gradient magnetic separation.

Professor Jim Watson has published over 200 papers, has 24 patents and has been a Fellow of the Institute of Physics since 1967.

A handout containing all relevant information about this lecture series will be a part of the proceedings. The lectures will be held after lunch on each of the three meeting days.

Tutorial on the Fundamentals and Applications of High Gradient Magnetic Separation (HGMS): This special feature consists of 3 half-hour lectures on a topic relevant to magnetic targeting and the use of magnetic microspheres given by professor Jim Watson.

 

 

 

 

GREGORY  LANZA,  Assistant Professor,  Doctor of sciences.

The Biomedical Engineering Department at the Washington University in St. Louis, MO, U.S.A.

Molecular Imaging and Targeted Drug Delivery with a Site-Specific Nanoparticle Platform Technology: Emerging Opportunities for Non-invasive Diagnosis and Image-Augmented Therapy

Doctor Lanza's research interests include site-targeted MRI and ultrasound contrast agents with magnetic nanoparticles, with or without drugs bound to them. He will present to us an in depth review of these exciting nanoparticles which have been used in vivo to target angiogenesis in solid tumors and early atherosclerosis.

 

 

 

 

 

JEAN - LOUIS  VIOVY,  Doctor of sciences.

Research Director of the «Macromolecules and Microsystems in Biology and Medicine» group at the Curie Institute in Paris, France. Magnetic Tweezers: Overview and Applications.

Doctor Viovy studies the interactions between DNA and several proteins essential for DNA repair and defense against mutagenic effects of ionizing radiation or chemical agents. To do this on a single molecule level and at time resolutions of microseconds to seconds, magnetic tweezers, the focus of this presentation, are the tool of choice.

 

 

 

 

 

ANDREAS  JORDAN,  Doctor of philosophy.

Senior Researcher at the Department of Radiation Oncology, University Clinic Charité, Berlin, Germany, and Director of MagForce Applications GmbH, Berlin, Germany. First Clinical Experience with Magnetic Fluid Hyperthermia (MFH) at the University Clinic Charité in Berlin, Germany.

Doctor Andreas Jordan has long been researching how alternating current (AC) magnetic fields heat magnetic fluids after injection into tumors. During the last couple of years, he built and tested a magnetic fluid hyperthermia machine for the treatment of cancer. In this presentation, he will give us first-hand the – spectacular ! – results of ongoing clinical trials.

 

 

 

 

MISCHA  MEGENS,  Doctor of philosophy.

Senior Scientist in the Integrated Device Technologies Group at Philips Research Laboratories, Eindhoven, Netherlands. Magnetic Biochips: A new Option for Sensitive Diagnostics.

Doctor Mischa Megens investigates miniaturised biosensor devices based on the detection of magnetic nanoparticles. The devices are made using semiconductor technology and integrated into a cartridge environment.  Dr. Megens will present an overview of magnetic particle based biosensing and its prospects to advance diagnostic tests.